Drug interactions
Hydrochlorothiazide-valsartan + Methyclothiazide
Severity: Moderate
Hydrochlorothiazide-valsartan and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyclothiazide is a thiazide diuretic, so combining it with hydrochlorothiazide duplicates therapy. This increases the risk of volume depletion, hypotension, hyponatremia, hypokalemia and renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duplicate thiazide diuretic activity at the distal convoluted tubule produces additive effects.
What to do
Avoid concurrent thiazides; if one is required, use a single agent and monitor electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Methyclothiazide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methyclothiazide is a thiazide diuretic, so combining it with hydrochlorothiazide duplicates therapy. This increases the risk of volume depletion, hypotension, hyponatremia, hypokalemia and renal impairment.
How serious is the interaction between Hydrochlorothiazide-valsartan and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent thiazides; if one is required, use a single agent and monitor electrolytes and renal function.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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