Drug interactions
Hydrochlorothiazide-valsartan + Nafcillin
Severity: Minor
Hydrochlorothiazide-valsartan and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and penicillins are both secreted by renal tubular organic anion transport, so they may compete for elimination. The clinical effect is small and rarely significant with nafcillin, which is cleared largely by the liver.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular organic anion secretion, though nafcillin relies mainly on biliary clearance.
What to do
No routine adjustment is needed; monitor blood pressure and electrolytes as usual during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Nafcillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and penicillins are both secreted by renal tubular organic anion transport, so they may compete for elimination. The clinical effect is small and rarely significant with nafcillin, which is cleared largely by the liver.
How serious is the interaction between Hydrochlorothiazide-valsartan and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure and electrolytes as usual during therapy.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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