Drug interactions
Hydrochlorothiazide-valsartan + Olodaterol inhaled
Severity: Minor
Hydrochlorothiazide-valsartan and Olodaterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide lowers potassium, and beta-2 agonists can further reduce it by shifting potassium into cells. Hypokalemia may be more important in patients at risk of arrhythmias, though inhaled doses give modest effects.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Olodaterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypokalemia from renal potassium wasting (thiazide) and intracellular potassium shift (beta-2 agonist).
What to do
Monitor serum potassium in patients with risk factors such as heart disease, hypoxia or high beta-agonist doses; replace potassium if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Olodaterol inhaled?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Olodaterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide lowers potassium, and beta-2 agonists can further reduce it by shifting potassium into cells. Hypokalemia may be more important in patients at risk of arrhythmias, though inhaled doses give modest effects.
How serious is the interaction between Hydrochlorothiazide-valsartan and Olodaterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with risk factors such as heart disease, hypoxia or high beta-agonist doses; replace potassium if low.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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