Drug interactions
Hydrochlorothiazide-valsartan + Pindolol
Severity: Moderate
Hydrochlorothiazide-valsartan and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol adds to the antihypertensive effect of valsartan and hydrochlorothiazide, which may cause hypotension or bradycardia. Beta-blockers can slightly raise potassium, adding to ARB effects.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood pressure lowering; beta-blockade modestly reduces cellular potassium uptake.
What to do
Monitor blood pressure, heart rate and potassium during initiation or dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Pindolol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pindolol adds to the antihypertensive effect of valsartan and hydrochlorothiazide, which may cause hypotension or bradycardia. Beta-blockers can slightly raise potassium, adding to ARB effects.
How serious is the interaction between Hydrochlorothiazide-valsartan and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium during initiation or dose changes.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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