Drug interactions
Hydrochlorothiazide-valsartan + Pirbuterol
Severity: Minor
Hydrochlorothiazide-valsartan and Pirbuterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and beta-2 agonists both lower serum potassium, which may increase arrhythmia risk in susceptible patients. Effects with inhaled pirbuterol are usually modest.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Pirbuterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypokalemia from renal potassium loss and beta-2-mediated cellular potassium uptake.
What to do
Check serum potassium in patients with heart disease or frequent beta-agonist use; replace potassium if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Pirbuterol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Pirbuterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide and beta-2 agonists both lower serum potassium, which may increase arrhythmia risk in susceptible patients. Effects with inhaled pirbuterol are usually modest.
How serious is the interaction between Hydrochlorothiazide-valsartan and Pirbuterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in patients with heart disease or frequent beta-agonist use; replace potassium if needed.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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