Drug interactions
Hydrochlorothiazide-valsartan + Propranolol
Severity: Minor
Hydrochlorothiazide-valsartan and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol with valsartan and hydrochlorothiazide produces additive blood pressure lowering, which can cause hypotension or bradycardia. Propranolol may also mask hypoglycemia symptoms, and thiazides can worsen glycemic control.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through beta-blockade, RAAS blockade and diuresis.
What to do
Monitor blood pressure and heart rate during initiation and titration. Monitor glucose in patients with diabetes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Propranolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol with valsartan and hydrochlorothiazide produces additive blood pressure lowering, which can cause hypotension or bradycardia. Propranolol may also mask hypoglycemia symptoms, and thiazides can worsen glycemic control.
How serious is the interaction between Hydrochlorothiazide-valsartan and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and titration. Monitor glucose in patients with diabetes.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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