Drug interactions
Hydrochlorothiazide-valsartan + Rifampin
Severity: Moderate
Hydrochlorothiazide-valsartan and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Single-dose rifampin inhibits OATP1B1 and may raise valsartan exposure, although with chronic dosing induction effects may offset this. The net clinical effect is uncertain.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin inhibits hepatic OATP1B1 uptake of valsartan, while chronic induction of transporters or enzymes may counteract it.
What to do
Monitor blood pressure and renal function after starting or stopping rifampin; adjust the valsartan dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Rifampin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Single-dose rifampin inhibits OATP1B1 and may raise valsartan exposure, although with chronic dosing induction effects may offset this. The net clinical effect is uncertain.
How serious is the interaction between Hydrochlorothiazide-valsartan and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function after starting or stopping rifampin; adjust the valsartan dose according to response.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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