Drug interactions
Hydrochlorothiazide-valsartan + Salicylates
Severity: Moderate
Hydrochlorothiazide-valsartan and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have weaker prostaglandin effects than other NSAIDs, but high doses may still blunt the antihypertensive effect and impair renal function when combined with a diuretic and ARB. Effect on potassium is variable.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of renal prostaglandins reducing sodium excretion and renal perfusion.
What to do
Monitor blood pressure, creatinine and potassium during regular or high-dose salicylate use, and keep the patient well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Salicylates?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have weaker prostaglandin effects than other NSAIDs, but high doses may still blunt the antihypertensive effect and impair renal function when combined with a diuretic and ARB. Effect on potassium is variable.
How serious is the interaction between Hydrochlorothiazide-valsartan and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium during regular or high-dose salicylate use, and keep the patient well hydrated.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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