Drug interactions
Hydrochlorothiazide-valsartan + Salsalate
Severity: Moderate
Hydrochlorothiazide-valsartan and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate with NSAID-like properties, can blunt the blood pressure lowering of valsartan and hydrochlorothiazide. In combination with a diuretic and an angiotensin receptor blocker it can also reduce renal function, especially in older or volume-depleted patients, and may raise potassium.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis reduces renal perfusion, sodium excretion and antihypertensive effect, while the combined hemodynamic effects add to the risk of acute kidney injury.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing salsalate, and ensure adequate hydration. Use the lowest effective salsalate dose for the shortest time, or choose an alternative analgesic where renal risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Salsalate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a salicylate with NSAID-like properties, can blunt the blood pressure lowering of valsartan and hydrochlorothiazide. In combination with a diuretic and an angiotensin receptor blocker it can also reduce renal function, especially in older or volume-depleted patients, and may raise potassium.
How serious is the interaction between Hydrochlorothiazide-valsartan and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing salsalate, and ensure adequate hydration. Use the lowest effective salsalate dose for the shortest time, or choose an alternative analgesic where renal risk is high.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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