Drug interactions
Hydrochlorothiazide-valsartan + Saquinavir
Severity: Minor
Hydrochlorothiazide-valsartan and Saquinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is taken up into the liver by OATP1B1, and saquinavir may inhibit this transporter. This could modestly raise valsartan exposure and strengthen its blood pressure lowering effect.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Saquinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan by saquinavir (boosted with ritonavir) reduces its hepatic clearance.
What to do
No empiric dose change is needed; monitor blood pressure and for hypotension or dizziness when starting or stopping the protease inhibitor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Saquinavir?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Saquinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is taken up into the liver by OATP1B1, and saquinavir may inhibit this transporter. This could modestly raise valsartan exposure and strengthen its blood pressure lowering effect.
How serious is the interaction between Hydrochlorothiazide-valsartan and Saquinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor blood pressure and for hypotension or dizziness when starting or stopping the protease inhibitor.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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