Drug interactions
Hydrochlorothiazide-valsartan + Shark cartilage
Severity: Minor
Hydrochlorothiazide-valsartan and Shark cartilage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shark cartilage supplements contain calcium and have been associated with hypercalcemia. Thiazides reduce urinary calcium excretion and could add to this risk, although clinical data are scarce.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive effect on serum calcium: calcium load from the supplement combined with reduced renal calcium excretion caused by hydrochlorothiazide.
What to do
Avoid unnecessary use of the supplement; if it is taken, check serum calcium periodically and stop it if hypercalcemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Shark cartilage?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shark cartilage supplements contain calcium and have been associated with hypercalcemia. Thiazides reduce urinary calcium excretion and could add to this risk, although clinical data are scarce.
How serious is the interaction between Hydrochlorothiazide-valsartan and Shark cartilage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary use of the supplement; if it is taken, check serum calcium periodically and stop it if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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