Drug interactions
Hydrochlorothiazide-valsartan + Shepherd's purse
Severity: Minor
Hydrochlorothiazide-valsartan and Shepherd's purse: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shepherd's purse has been reported to affect blood pressure, so it could theoretically interfere with control achieved by antihypertensives. Reliable clinical evidence is lacking.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Shepherd's purse have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not established; theoretical effects of plant constituents on vascular tone.
What to do
Advise patients to avoid the herb if blood pressure is difficult to control, and monitor blood pressure if it is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Shepherd's purse?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Shepherd's purse have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shepherd's purse has been reported to affect blood pressure, so it could theoretically interfere with control achieved by antihypertensives. Reliable clinical evidence is lacking.
How serious is the interaction between Hydrochlorothiazide-valsartan and Shepherd's purse?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid the herb if blood pressure is difficult to control, and monitor blood pressure if it is used.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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