Drug interactions
Hydrochlorothiazide-valsartan + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Hydrochlorothiazide-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations cause fluid loss and electrolyte shifts. In patients taking a thiazide diuretic and an angiotensin receptor blocker, this raises the risk of dehydration, electrolyte disturbance, arrhythmia and acute kidney injury.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte disturbance from the osmotic purgative, the diuretic, and the renal hemodynamic effects of the angiotensin receptor blocker.
What to do
Ensure adequate fluid intake during bowel preparation and consider withholding the diuretic and valsartan on the day of the preparation. Check electrolytes and renal function beforehand in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations cause fluid loss and electrolyte shifts. In patients taking a thiazide diuretic and an angiotensin receptor blocker, this raises the risk of dehydration, electrolyte disturbance, arrhythmia and acute kidney injury.
How serious is the interaction between Hydrochlorothiazide-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate fluid intake during bowel preparation and consider withholding the diuretic and valsartan on the day of the preparation. Check electrolytes and renal function beforehand in high-risk patients.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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