Drug interactions
Hydrochlorothiazide-valsartan + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Hydrochlorothiazide-valsartan and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-salt bowel cleansing preparations cause fluid shifts and electrolyte abnormalities. With a thiazide and an angiotensin receptor blocker the risk of dehydration, arrhythmia, seizures from hyponatremia and kidney injury is increased.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte disturbance from the osmotic purgative, the diuretic, and the renal hemodynamic effects of the angiotensin receptor blocker.
What to do
Encourage adequate hydration and consider holding the diuretic and valsartan on the preparation day. Check electrolytes and renal function in older patients or those with kidney disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-salt bowel cleansing preparations cause fluid shifts and electrolyte abnormalities. With a thiazide and an angiotensin receptor blocker the risk of dehydration, arrhythmia, seizures from hyponatremia and kidney injury is increased.
How serious is the interaction between Hydrochlorothiazide-valsartan and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Encourage adequate hydration and consider holding the diuretic and valsartan on the preparation day. Check electrolytes and renal function in older patients or those with kidney disease.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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