Drug interactions
Hydrochlorothiazide-valsartan + Synthetic human angiotensin ii
Severity: Moderate
Hydrochlorothiazide-valsartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan blocks AT1 receptors, so it opposes the pressor effect of exogenous angiotensin II given for vasodilatory shock. Patients taking an ARB may need higher angiotensin II doses to reach target blood pressure.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at the angiotensin II type 1 receptor.
What to do
Titrate angiotensin II to blood pressure response and anticipate higher dose requirements in patients on recent ARB therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan blocks AT1 receptors, so it opposes the pressor effect of exogenous angiotensin II given for vasodilatory shock. Patients taking an ARB may need higher angiotensin II doses to reach target blood pressure.
How serious is the interaction between Hydrochlorothiazide-valsartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II to blood pressure response and anticipate higher dose requirements in patients on recent ARB therapy.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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