Drug interactions
Hydrochlorothiazide-valsartan + Terbutaline
Severity: Moderate
Hydrochlorothiazide-valsartan and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline and hydrochlorothiazide both lower serum potassium, and the combination may cause significant hypokalemia, especially with higher or systemic terbutaline doses. This can predispose to arrhythmias and ECG changes.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Additive hypokalemia from thiazide renal potassium loss and beta-2 agonist intracellular potassium shift.
What to do
Monitor serum potassium, particularly with systemic or high-dose terbutaline. Supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Terbutaline
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Terbutaline?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline and hydrochlorothiazide both lower serum potassium, and the combination may cause significant hypokalemia, especially with higher or systemic terbutaline doses. This can predispose to arrhythmias and ECG changes.
How serious is the interaction between Hydrochlorothiazide-valsartan and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with systemic or high-dose terbutaline. Supplement potassium if needed.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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