Drug interactions
Hydrochlorothiazide-valsartan + Trilostane
Severity: Moderate
Hydrochlorothiazide-valsartan and Trilostane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilostane inhibits adrenal steroid synthesis including aldosterone, which can lead to potassium retention and sodium loss. With valsartan, which also reduces aldosterone effect, this raises the risk of hyperkalemia and hypotension.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive suppression of aldosterone activity through inhibition of adrenal steroid synthesis and angiotensin receptor blockade.
What to do
Monitor serum potassium, sodium and blood pressure when the combination is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Trilostane?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilostane inhibits adrenal steroid synthesis including aldosterone, which can lead to potassium retention and sodium loss. With valsartan, which also reduces aldosterone effect, this raises the risk of hyperkalemia and hypotension.
How serious is the interaction between Hydrochlorothiazide-valsartan and Trilostane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium and blood pressure when the combination is used.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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