Drug interactions
Hydrochlorothiazide-valsartan + Umeclidinium bromide / vilanterol inhaled
Severity: Minor
Hydrochlorothiazide-valsartan and Umeclidinium bromide / vilanterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-agonists such as vilanterol can lower serum potassium and cause ECG changes, which may be worsened by thiazide-induced potassium loss. The effect is generally small at recommended inhaler doses but matters with higher doses or susceptible patients.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta-2 stimulated intracellular potassium shift combined with renal potassium wasting from the thiazide.
What to do
Check serum potassium in patients with additional risk factors, and ensure the inhaler dose is not exceeded.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-agonists such as vilanterol can lower serum potassium and cause ECG changes, which may be worsened by thiazide-induced potassium loss. The effect is generally small at recommended inhaler doses but matters with higher doses or susceptible patients.
How serious is the interaction between Hydrochlorothiazide-valsartan and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in patients with additional risk factors, and ensure the inhaler dose is not exceeded.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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