Drug interactions
Hydrochlorothiazide-valsartan + Vilanterol / fluticasone furoate inhaled
Severity: Minor
Hydrochlorothiazide-valsartan and Vilanterol / fluticasone furoate inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol can lower serum potassium and may worsen ECG changes, and thiazide diuretics add to potassium loss. At standard inhaled doses the effect is usually modest.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta-2 mediated potassium shift into cells plus thiazide renal potassium wasting.
What to do
Monitor serum potassium in patients with other hypokalemia risk factors, and avoid exceeding the recommended inhaler dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilanterol can lower serum potassium and may worsen ECG changes, and thiazide diuretics add to potassium loss. At standard inhaled doses the effect is usually modest.
How serious is the interaction between Hydrochlorothiazide-valsartan and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with other hypokalemia risk factors, and avoid exceeding the recommended inhaler dose.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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