Drug interactions
Hydrochlorothiazide-valsartan + Willow bark
Severity: Minor
Hydrochlorothiazide-valsartan and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, converted to salicylates, which may blunt the antihypertensive and diuretic effect of thiazides and ARBs and may impair renal function. The effect is smaller than with NSAIDs but is relevant with chronic use.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate-mediated inhibition of renal prostaglandin synthesis and competition for tubular secretion.
What to do
Monitor blood pressure and renal function if willow bark is used regularly, especially in volume-depleted patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Willow bark?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, converted to salicylates, which may blunt the antihypertensive and diuretic effect of thiazides and ARBs and may impair renal function. The effect is smaller than with NSAIDs but is relevant with chronic use.
How serious is the interaction between Hydrochlorothiazide-valsartan and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if willow bark is used regularly, especially in volume-depleted patients.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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