Drug interactions
Hydrocortisone + Insulin degludec-liraglutide
Severity: Moderate
Hydrocortisone and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as hydrocortisone cause hyperglycemia and insulin resistance, which oppose the effect of insulin and liraglutide. Higher doses or prolonged courses can substantially worsen control, and hypoglycemia can occur when the steroid is reduced.
What this interaction means in plain words
Hydrocortisone and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and peripheral insulin resistance, antagonizing antidiabetic drugs.
What to do
Monitor blood glucose more often during systemic steroid therapy and increase the insulin dose as required. Reduce the dose again when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Hydrocortisone and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as hydrocortisone cause hyperglycemia and insulin resistance, which oppose the effect of insulin and liraglutide. Higher doses or prolonged courses can substantially worsen control, and hypoglycemia can occur when the steroid is reduced.
How serious is the interaction between Hydrocortisone and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often during systemic steroid therapy and increase the insulin dose as required. Reduce the dose again when the steroid is tapered.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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