Drug interactions
Hydrocortisone + Insulin glargine-lixisenatide
Severity: Moderate
Hydrocortisone and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic hydrocortisone raises blood glucose and can reduce the effectiveness of insulin and GLP-1 therapy. The effect depends on dose and duration, and is greater with supraphysiologic doses.
What this interaction means in plain words
Hydrocortisone and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and peripheral insulin resistance, opposing glucose lowering.
What to do
Monitor blood glucose during systemic hydrocortisone therapy and titrate the insulin dose upward as needed. Reduce it again when the steroid dose is lowered or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Hydrocortisone and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic hydrocortisone raises blood glucose and can reduce the effectiveness of insulin and GLP-1 therapy. The effect depends on dose and duration, and is greater with supraphysiologic doses.
How serious is the interaction between Hydrocortisone and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during systemic hydrocortisone therapy and titrate the insulin dose upward as needed. Reduce it again when the steroid dose is lowered or stopped.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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