Drug interactions
Hydrocortisone + Istradefylline
Severity: Minor
Hydrocortisone and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses increases exposure to P-gp substrates. Hydrocortisone is a P-gp substrate, but the clinical effect is expected to be small.
What this interaction means in plain words
Hydrocortisone and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits P-glycoprotein, possibly increasing hydrocortisone absorption and reducing efflux.
What to do
No routine adjustment is needed. Monitor for signs of corticosteroid excess with long-term combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Hydrocortisone with Istradefylline?
MediHelp rates the interaction as minor. Hydrocortisone and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses increases exposure to P-gp substrates. Hydrocortisone is a P-gp substrate, but the clinical effect is expected to be small.
How serious is the interaction between Hydrocortisone and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for signs of corticosteroid excess with long-term combined use.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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