Drug interactions
Hydrocortisone + Metformin-repaglinide
Severity: Moderate
Hydrocortisone and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone raises blood glucose through glucocorticoid effects, which can substantially counteract antidiabetic treatment. Any CYP3A4 induction effect on repaglinide is minor in comparison.
What this interaction means in plain words
Hydrocortisone and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose output, with possible minor CYP3A4 induction.
What to do
Monitor blood glucose during corticosteroid therapy and increase antidiabetic doses as required, reducing them again when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrocortisone and Metformin-repaglinide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-repaglinide
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Hydrocortisone and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone raises blood glucose through glucocorticoid effects, which can substantially counteract antidiabetic treatment. Any CYP3A4 induction effect on repaglinide is minor in comparison.
How serious is the interaction between Hydrocortisone and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during corticosteroid therapy and increase antidiabetic doses as required, reducing them again when the steroid is tapered.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
