Drug interactions
Hydrocortisone + Oxcarbazepine
Severity: Moderate
Hydrocortisone and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak-to-moderate CYP3A4 inducer and may reduce exposure to hydrocortisone, potentially diminishing glucocorticoid effect. This is most relevant in adrenal insufficiency patients on replacement doses.
What this interaction means in plain words
Hydrocortisone and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4-mediated hydrocortisone metabolism by oxcarbazepine.
What to do
Monitor for loss of steroid effect or adrenal insufficiency symptoms and increase the hydrocortisone dose if required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Hydrocortisone with Oxcarbazepine?
MediHelp rates the interaction as moderate. Hydrocortisone and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak-to-moderate CYP3A4 inducer and may reduce exposure to hydrocortisone, potentially diminishing glucocorticoid effect. This is most relevant in adrenal insufficiency patients on replacement doses.
How serious is the interaction between Hydrocortisone and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of steroid effect or adrenal insufficiency symptoms and increase the hydrocortisone dose if required.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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