Drug interactions
Hydrocortisone + Pazopanib
Severity: Minor
Hydrocortisone and Pazopanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone may weakly induce CYP3A4 and slightly reduce pazopanib exposure. The effect is expected to be small, but reduced pazopanib concentrations could affect antitumor efficacy.
What this interaction means in plain words
Hydrocortisone and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Pazopanib belongs to Oncology.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone increasing pazopanib metabolism.
What to do
No dose change is needed routinely. Monitor tumor response if sustained high-dose corticosteroid therapy is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Hydrocortisone with Pazopanib?
MediHelp rates the interaction as minor. Hydrocortisone and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone may weakly induce CYP3A4 and slightly reduce pazopanib exposure. The effect is expected to be small, but reduced pazopanib concentrations could affect antitumor efficacy.
How serious is the interaction between Hydrocortisone and Pazopanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Monitor tumor response if sustained high-dose corticosteroid therapy is required.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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