Drug interactions
Hydrocortisone + Sargramostim
Severity: Minor
Hydrocortisone and Sargramostim: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can raise neutrophil counts through demargination, which may add to the leukocytosis caused by sargramostim. Corticosteroids may also blunt the inflammatory actions of the growth factor.
What this interaction means in plain words
Hydrocortisone and Sargramostim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Sargramostim belongs to Miscellaneous.
Why it happens
Additive increase in circulating white cells via corticosteroid demargination plus colony-stimulating factor effect.
What to do
Monitor white blood cell counts and interpret leukocytosis with the steroid effect in mind.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrocortisone and Sargramostim, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Sargramostim
- Ifosfamide + Sargramostim Moderate
- Lithium + Sargramostim Minor
Frequently asked questions
Can I take Hydrocortisone with Sargramostim?
MediHelp rates the interaction as minor. Hydrocortisone and Sargramostim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids can raise neutrophil counts through demargination, which may add to the leukocytosis caused by sargramostim. Corticosteroids may also blunt the inflammatory actions of the growth factor.
How serious is the interaction between Hydrocortisone and Sargramostim?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor white blood cell counts and interpret leukocytosis with the steroid effect in mind.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
