Drug interactions
Hydrocortisone + Somapacitan
Severity: Moderate
Hydrocortisone and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone inhibits 11-beta-HSD1, reducing conversion of cortisone to active cortisol, which can unmask or worsen cortisol deficiency in patients on replacement therapy. Conversely, supraphysiologic glucocorticoid doses can blunt the growth-promoting effect of somapacitan.
What this interaction means in plain words
Hydrocortisone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone inhibits 11-beta-HSD1, lowering cortisol generation, while glucocorticoids pharmacodynamically antagonize growth hormone effects.
What to do
Reassess glucocorticoid replacement after starting somapacitan and increase maintenance or stress doses if needed. In growing children, use the lowest glucocorticoid dose that controls the condition and monitor growth.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Hydrocortisone with Somapacitan?
MediHelp rates the interaction as moderate. Hydrocortisone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone inhibits 11-beta-HSD1, reducing conversion of cortisone to active cortisol, which can unmask or worsen cortisol deficiency in patients on replacement therapy. Conversely, supraphysiologic glucocorticoid doses can blunt the growth-promoting effect of somapacitan.
How serious is the interaction between Hydrocortisone and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reassess glucocorticoid replacement after starting somapacitan and increase maintenance or stress doses if needed. In growing children, use the lowest glucocorticoid dose that controls the condition and monitor growth.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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