Drug interactions
Hydrocortisone + Somatrogon
Severity: Moderate
Hydrocortisone and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Supraphysiologic glucocorticoid doses can attenuate the growth-promoting effect of somatrogon. Growth hormone analogs also inhibit 11-beta-HSD1, which may reduce cortisol activation and unmask hypoadrenalism in patients on replacement therapy.
What this interaction means in plain words
Hydrocortisone and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Glucocorticoids antagonize growth hormone action, and growth hormone inhibits 11-beta-HSD1.
What to do
Titrate glucocorticoid replacement after starting somatrogon and increase doses if signs of cortisol deficiency appear. Keep glucocorticoid dosing as low as possible and track growth.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrocortisone and Somatrogon, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Hydrocortisone with Somatrogon?
MediHelp rates the interaction as moderate. Hydrocortisone and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Supraphysiologic glucocorticoid doses can attenuate the growth-promoting effect of somatrogon. Growth hormone analogs also inhibit 11-beta-HSD1, which may reduce cortisol activation and unmask hypoadrenalism in patients on replacement therapy.
How serious is the interaction between Hydrocortisone and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate glucocorticoid replacement after starting somatrogon and increase doses if signs of cortisol deficiency appear. Keep glucocorticoid dosing as low as possible and track growth.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
