Drug interactions
Hydrocortisone + Sorafenib
Severity: Minor
Hydrocortisone and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is a weak CYP3A4 inducer, but sorafenib is cleared mainly by CYP3A4 and UGT1A9. A clinically important fall in sorafenib exposure is not well established.
What this interaction means in plain words
Hydrocortisone and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Sorafenib belongs to Oncology.
Why it happens
Possible weak induction of CYP3A4-mediated sorafenib metabolism.
What to do
No empirical dose adjustment is needed. Monitor for reduced tumor response during prolonged high-dose steroid therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Hydrocortisone with Sorafenib?
MediHelp rates the interaction as minor. Hydrocortisone and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is a weak CYP3A4 inducer, but sorafenib is cleared mainly by CYP3A4 and UGT1A9. A clinically important fall in sorafenib exposure is not well established.
How serious is the interaction between Hydrocortisone and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed. Monitor for reduced tumor response during prolonged high-dose steroid therapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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