Drug interactions
Hydrocortisone + Sotorasib
Severity: Moderate
Hydrocortisone and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak P-gp inducer and CYP3A4 inducer, so it could modestly lower hydrocortisone exposure. The clinical consequence is likely small but could matter in adrenal insufficiency.
What this interaction means in plain words
Hydrocortisone and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Sotorasib belongs to Oncology.
Why it happens
Sotorasib induces CYP3A4 and P-gp, potentially reducing hydrocortisone exposure.
What to do
Monitor for reduced glucocorticoid effect and adjust the hydrocortisone dose if symptoms of under-replacement appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Hydrocortisone with Sotorasib?
MediHelp rates the interaction as moderate. Hydrocortisone and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a weak P-gp inducer and CYP3A4 inducer, so it could modestly lower hydrocortisone exposure. The clinical consequence is likely small but could matter in adrenal insufficiency.
How serious is the interaction between Hydrocortisone and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced glucocorticoid effect and adjust the hydrocortisone dose if symptoms of under-replacement appear.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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