Drug interactions
Hydrocortisone + Tinzaparin
Severity: Moderate
Hydrocortisone and Tinzaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can raise bleeding risk through effects on vascular integrity and gastric mucosa, and tinzaparin is an anticoagulant. The effect on anticoagulation itself is inconsistent, and INR is not a useful monitor for low molecular weight heparin.
What this interaction means in plain words
Hydrocortisone and Tinzaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Tinzaparin belongs to Cardiovascular.
Why it happens
Additive bleeding risk from anticoagulation and corticosteroid-related mucosal and vascular fragility; no direct pharmacokinetic interaction.
What to do
Monitor for signs of bleeding, particularly GI bleeding, and check hemoglobin and platelets periodically. Consider gastric protection when steroids are used at high doses or for long periods.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Tinzaparin
Frequently asked questions
Can I take Hydrocortisone with Tinzaparin?
MediHelp rates the interaction as moderate. Hydrocortisone and Tinzaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can raise bleeding risk through effects on vascular integrity and gastric mucosa, and tinzaparin is an anticoagulant. The effect on anticoagulation itself is inconsistent, and INR is not a useful monitor for low molecular weight heparin.
How serious is the interaction between Hydrocortisone and Tinzaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, particularly GI bleeding, and check hemoglobin and platelets periodically. Consider gastric protection when steroids are used at high doses or for long periods.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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