Drug interactions
Mifepristone + Tinzaparin
Severity: Major
Mifepristone and Tinzaparin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is used to end pregnancy and is associated with prolonged uterine bleeding. In a patient receiving full-dose anticoagulation such as tinzaparin, bleeding may be heavier or harder to control. Labeling advises against use in patients on anticoagulant therapy.
What this interaction means in plain words
Mifepristone and Tinzaparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Tinzaparin belongs to Cardiovascular.
Why it happens
Additive bleeding risk: mifepristone-induced uterine bleeding is combined with the anticoagulant effect of tinzaparin.
What to do
Avoid mifepristone for pregnancy termination in patients on therapeutic anticoagulation unless anticoagulation is held under specialist guidance. If it cannot be avoided, monitor bleeding and hemoglobin closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Tinzaparin
- Hydrocortisone + Tinzaparin Moderate
Frequently asked questions
Can I take Mifepristone with Tinzaparin?
MediHelp rates the interaction as major. Mifepristone and Tinzaparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone is used to end pregnancy and is associated with prolonged uterine bleeding. In a patient receiving full-dose anticoagulation such as tinzaparin, bleeding may be heavier or harder to control. Labeling advises against use in patients on anticoagulant therapy.
How serious is the interaction between Mifepristone and Tinzaparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid mifepristone for pregnancy termination in patients on therapeutic anticoagulation unless anticoagulation is held under specialist guidance. If it cannot be avoided, monitor bleeding and hemoglobin closely.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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