Drug interactions
Hydrocortisone + Trastuzumab
Severity: Minor
Hydrocortisone and Trastuzumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids are immunosuppressive, and trastuzumab combined with myelosuppressive chemotherapy raises neutropenia and infection risk. Hydrocortisone is often given as premedication for infusion reactions at limited doses, and there is no direct interaction between the two drugs.
What this interaction means in plain words
Hydrocortisone and Trastuzumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Trastuzumab belongs to Oncology.
Why it happens
No direct interaction; the corticosteroid's immunosuppression may be additive with treatment-related neutropenia.
What to do
No specific action is needed for premedication use. Monitor for infection and blood counts during prolonged steroid exposure with chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Hydrocortisone with Trastuzumab?
MediHelp rates the interaction as minor. Hydrocortisone and Trastuzumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids are immunosuppressive, and trastuzumab combined with myelosuppressive chemotherapy raises neutropenia and infection risk. Hydrocortisone is often given as premedication for infusion reactions at limited doses, and there is no direct interaction between the two drugs.
How serious is the interaction between Hydrocortisone and Trastuzumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed for premedication use. Monitor for infection and blood counts during prolonged steroid exposure with chemotherapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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