Drug interactions
Hydrocortisone + Ublituximab
Severity: Moderate
Hydrocortisone and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells and hydrocortisone suppresses immune function, so concurrent use may increase the risk of infection. Corticosteroids are also given as premedication to reduce infusion reactions, which is an intended short-term use.
What this interaction means in plain words
Hydrocortisone and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from anti-CD20 B-cell depletion and glucocorticoid effects on lymphocytes.
What to do
Use steroid premedication as directed for infusions, but avoid additional prolonged systemic immunosuppression where possible. Monitor for infections and screen for hepatitis B before treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Ublituximab
Frequently asked questions
Can I take Hydrocortisone with Ublituximab?
MediHelp rates the interaction as moderate. Hydrocortisone and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells and hydrocortisone suppresses immune function, so concurrent use may increase the risk of infection. Corticosteroids are also given as premedication to reduce infusion reactions, which is an intended short-term use.
How serious is the interaction between Hydrocortisone and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use steroid premedication as directed for infusions, but avoid additional prolonged systemic immunosuppression where possible. Monitor for infections and screen for hepatitis B before treatment.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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