Drug interactions
Hydrocortisone rectal + Ofloxacin
Severity: Minor
Hydrocortisone rectal and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids raise the risk of fluoroquinolone-associated tendon injury. Rectal hydrocortisone is partly absorbed, so the additive risk is smaller than with oral or injected steroids but not absent with prolonged use.
What this interaction means in plain words
Hydrocortisone rectal and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive tendon toxicity from fluoroquinolone effects and corticosteroid-mediated collagen impairment, limited by low systemic exposure.
What to do
Counsel the patient to stop ofloxacin and report tendon pain or swelling promptly. Be more cautious in older patients or with prolonged rectal steroid use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Hydrocortisone rectal with Ofloxacin?
MediHelp rates the interaction as minor. Hydrocortisone rectal and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic corticosteroids raise the risk of fluoroquinolone-associated tendon injury. Rectal hydrocortisone is partly absorbed, so the additive risk is smaller than with oral or injected steroids but not absent with prolonged use.
How serious is the interaction between Hydrocortisone rectal and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to stop ofloxacin and report tendon pain or swelling promptly. Be more cautious in older patients or with prolonged rectal steroid use.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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