Drug interactions
Hydroxyprogesterone caproate + Insulin degludec
Severity: Minor
Hydroxyprogesterone caproate and Insulin degludec: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can reduce glucose tolerance and insulin sensitivity. Insulin degludec effectiveness may be slightly reduced, with higher glucose readings.
What this interaction means in plain words
Hydroxyprogesterone caproate and Insulin degludec have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism through progestin-related insulin resistance.
What to do
Monitor blood glucose during treatment, especially in pregnancy. Adjust insulin degludec if readings rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Insulin degludec?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Insulin degludec have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can reduce glucose tolerance and insulin sensitivity. Insulin degludec effectiveness may be slightly reduced, with higher glucose readings.
How serious is the interaction between Hydroxyprogesterone caproate and Insulin degludec?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during treatment, especially in pregnancy. Adjust insulin degludec if readings rise.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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