Drug interactions
Hydroxyprogesterone caproate + Ketoconazole
Severity: Minor
Hydroxyprogesterone caproate and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise exposure to hydroxyprogesterone caproate, which is partly cleared by CYP3A enzymes. The clinical consequence is uncertain, but higher progestin exposure could increase progestogenic adverse effects.
What this interaction means in plain words
Hydroxyprogesterone caproate and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ketoconazole inhibits CYP3A4-mediated metabolism of hydroxyprogesterone caproate.
What to do
No routine dose change is needed; watch for increased progestogenic adverse effects such as fluid retention or injection-site and mood effects during prolonged azole therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Ketoconazole?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may raise exposure to hydroxyprogesterone caproate, which is partly cleared by CYP3A enzymes. The clinical consequence is uncertain, but higher progestin exposure could increase progestogenic adverse effects.
How serious is the interaction between Hydroxyprogesterone caproate and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for increased progestogenic adverse effects such as fluid retention or injection-site and mood effects during prolonged azole therapy.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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