Drug interactions
Hydroxyprogesterone caproate + Lorlatinib
Severity: Moderate
Hydroxyprogesterone caproate and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyprogesterone caproate is metabolized partly by CYP3A4, so lorlatinib may lower its levels and reduce effect.
What this interaction means in plain words
Hydroxyprogesterone caproate and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lorlatinib induces CYP3A4, increasing hydroxyprogesterone caproate metabolism.
What to do
Monitor for reduced therapeutic response. Consider an alternative progestin if efficacy is needed and lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Lorlatinib?
MediHelp rates the interaction as moderate. Hydroxyprogesterone caproate and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyprogesterone caproate is metabolized partly by CYP3A4, so lorlatinib may lower its levels and reduce effect.
How serious is the interaction between Hydroxyprogesterone caproate and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced therapeutic response. Consider an alternative progestin if efficacy is needed and lost.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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