Drug interactions
Hydroxyprogesterone caproate + Nortriptyline
Severity: Minor
Hydroxyprogesterone caproate and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is little evidence that hydroxyprogesterone caproate meaningfully affects nortriptyline, and any interaction is theoretical, extrapolated from sex hormone effects on tricyclic metabolism.
What this interaction means in plain words
Hydroxyprogesterone caproate and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical alteration of hepatic metabolism of tricyclics by sex hormones; not established for this drug.
What to do
No routine adjustment is needed; monitor for changes in antidepressant response or adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Nortriptyline?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is little evidence that hydroxyprogesterone caproate meaningfully affects nortriptyline, and any interaction is theoretical, extrapolated from sex hormone effects on tricyclic metabolism.
How serious is the interaction between Hydroxyprogesterone caproate and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for changes in antidepressant response or adverse effects.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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