Drug interactions
Hydroxyurea + Interferon gamma 1b
Severity: Moderate
Hydroxyurea and Interferon gamma 1b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cutaneous vasculitic toxicities, including ulceration and gangrene, have been reported when hydroxyurea is given to patients with current or past interferon therapy. Interferon gamma specifically is less documented than alpha interferons.
What this interaction means in plain words
Hydroxyurea and Interferon gamma 1b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism not established; possibly additive vascular and cutaneous toxicity.
What to do
Examine the skin and extremities regularly. Discontinue hydroxyurea if vasculitic ulcers develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydroxyurea and Interferon gamma 1b, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Interferon gamma 1b?
MediHelp rates the interaction as moderate. Hydroxyurea and Interferon gamma 1b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cutaneous vasculitic toxicities, including ulceration and gangrene, have been reported when hydroxyurea is given to patients with current or past interferon therapy. Interferon gamma specifically is less documented than alpha interferons.
How serious is the interaction between Hydroxyurea and Interferon gamma 1b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Examine the skin and extremities regularly. Discontinue hydroxyurea if vasculitic ulcers develop.
What other medicines interact with Hydroxyurea?
MediHelp also lists interactions of Hydroxyurea with, for example, Didanosine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Hydroxyurea page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
