Drug interactions
Hydroxyurea + Methotrexate
Severity: Moderate
Hydroxyurea and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow function, so combined use may deepen leukopenia, anemia and thrombocytopenia. Both can also contribute to mucocutaneous toxicity.
What this interaction means in plain words
Hydroxyurea and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Methotrexate belongs to Oncology.
Why it happens
Additive myelosuppression through different antiproliferative mechanisms.
What to do
Monitor complete blood count frequently and adjust doses of either drug for cytopenias. Delay therapy until counts recover if severe suppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Methotrexate?
MediHelp rates the interaction as moderate. Hydroxyurea and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow function, so combined use may deepen leukopenia, anemia and thrombocytopenia. Both can also contribute to mucocutaneous toxicity.
How serious is the interaction between Hydroxyurea and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood count frequently and adjust doses of either drug for cytopenias. Delay therapy until counts recover if severe suppression occurs.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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