Drug interactions
Hydroxyurea + Pentostatin
Severity: Moderate
Hydroxyurea and Pentostatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow and immune function. Together they can increase the risk of cytopenias and opportunistic infections.
What this interaction means in plain words
Hydroxyurea and Pentostatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Pentostatin belongs to Oncology.
Why it happens
Additive myelosuppressive and immunosuppressive effects.
What to do
Monitor blood counts and for infection. Reduce or hold doses if severe cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyurea
Other interactions of Pentostatin
- Carmustine + Pentostatin Contraindicated
- Etoposide + Pentostatin Contraindicated
- Fludarabine + Pentostatin Contraindicated
- Cyclophosphamide + Pentostatin Major
- Deferiprone + Pentostatin Major
- Fingolimod + Pentostatin Major
Frequently asked questions
Can I take Hydroxyurea with Pentostatin?
MediHelp rates the interaction as moderate. Hydroxyurea and Pentostatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow and immune function. Together they can increase the risk of cytopenias and opportunistic infections.
How serious is the interaction between Hydroxyurea and Pentostatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for infection. Reduce or hold doses if severe cytopenias develop.
What other medicines interact with Hydroxyurea?
MediHelp also lists interactions of Hydroxyurea with, for example, Didanosine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Hydroxyurea page.
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