Drug interactions
Hydroxyurea + Thiotepa
Severity: Major
Hydroxyurea and Thiotepa: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are strongly myelosuppressive, and thiotepa at high doses causes profound marrow ablation. Added hydroxyurea can worsen and prolong cytopenias, with risk of serious infection and bleeding.
What this interaction means in plain words
Hydroxyurea and Thiotepa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyurea belongs to Miscellaneous; Thiotepa belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Avoid combining if possible, or monitor blood counts closely and reduce doses. Provide supportive care such as transfusions and growth factors as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxyurea
Other interactions of Thiotepa
- Bendamustine + Thiotepa Major
- Chlorambucil + Thiotepa Major
- Clarithromycin + Thiotepa Major
- Cyclophosphamide + Thiotepa Major
- Dacarbazine + Thiotepa Major
- Deferiprone + Thiotepa Major
Frequently asked questions
Can I take Hydroxyurea with Thiotepa?
MediHelp rates the interaction as major. Hydroxyurea and Thiotepa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are strongly myelosuppressive, and thiotepa at high doses causes profound marrow ablation. Added hydroxyurea can worsen and prolong cytopenias, with risk of serious infection and bleeding.
How serious is the interaction between Hydroxyurea and Thiotepa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible, or monitor blood counts closely and reduce doses. Provide supportive care such as transfusions and growth factors as needed.
What other medicines interact with Hydroxyurea?
MediHelp also lists interactions of Hydroxyurea with, for example, Didanosine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Hydroxyurea page.
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