Drug interactions
Hydroxyurea + Typhoid vaccine live
Severity: Moderate
Hydroxyurea and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) may be less effective during hydroxyurea therapy. The live bacteria could also cause infection in an immunosuppressed patient.
What this interaction means in plain words
Hydroxyurea and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression lowers the immune response to the vaccine and may allow replication of the live attenuated organism.
What to do
Use the inactivated parenteral typhoid vaccine instead during hydroxyurea therapy. Complete any live vaccination before starting treatment, with adequate lead time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Hydroxyurea and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine (Ty21a) may be less effective during hydroxyurea therapy. The live bacteria could also cause infection in an immunosuppressed patient.
How serious is the interaction between Hydroxyurea and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inactivated parenteral typhoid vaccine instead during hydroxyurea therapy. Complete any live vaccination before starting treatment, with adequate lead time.
What other medicines interact with Hydroxyurea?
MediHelp also lists interactions of Hydroxyurea with, for example, Didanosine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Hydroxyurea page.
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