Drug interactions
Ibrutinib + Isoniazid
Severity: Moderate
Ibrutinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib is extensively metabolized by CYP3A4, and inhibition by isoniazid may raise its exposure. This increases the risk of bleeding, atrial fibrillation and infection.
What this interaction means in plain words
Ibrutinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, reducing ibrutinib clearance.
What to do
Monitor for bleeding, arrhythmias and cytopenias. Consider reducing the ibrutinib dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Isoniazid?
MediHelp rates the interaction as moderate. Ibrutinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib is extensively metabolized by CYP3A4, and inhibition by isoniazid may raise its exposure. This increases the risk of bleeding, atrial fibrillation and infection.
How serious is the interaction between Ibrutinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, arrhythmias and cytopenias. Consider reducing the ibrutinib dose if toxicity appears.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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