Drug interactions
Ibrutinib + Venlafaxine
Severity: Moderate
Ibrutinib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and increases the risk of bleeding. Venlafaxine reduces platelet serotonin uptake and also adds to bleeding risk, particularly gastrointestinal bleeding. The combination may increase the frequency or severity of hemorrhage.
What this interaction means in plain words
Ibrutinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function through BTK inhibition and reduced platelet serotonin storage.
What to do
Monitor for bruising, melena and other bleeding, and check blood counts periodically. Reassess the need for additional antiplatelet or anticoagulant drugs and consider gastroprotection in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Venlafaxine?
MediHelp rates the interaction as moderate. Ibrutinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and increases the risk of bleeding. Venlafaxine reduces platelet serotonin uptake and also adds to bleeding risk, particularly gastrointestinal bleeding. The combination may increase the frequency or severity of hemorrhage.
How serious is the interaction between Ibrutinib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising, melena and other bleeding, and check blood counts periodically. Reassess the need for additional antiplatelet or anticoagulant drugs and consider gastroprotection in higher-risk patients.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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