Drug interactions
Ibuprofen + Indapamide
Severity: Moderate
Ibuprofen and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may attenuate the antihypertensive and diuretic effects of indapamide. Together with a diuretic, NSAIDs also raise the risk of acute kidney injury, especially with dehydration.
What this interaction means in plain words
Ibuprofen and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Indapamide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, opposing diuretic action.
What to do
Monitor blood pressure, hydration and serum creatinine and electrolytes; use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Indapamide
Frequently asked questions
Can I take Ibuprofen with Indapamide?
MediHelp rates the interaction as moderate. Ibuprofen and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen may attenuate the antihypertensive and diuretic effects of indapamide. Together with a diuretic, NSAIDs also raise the risk of acute kidney injury, especially with dehydration.
How serious is the interaction between Ibuprofen and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, hydration and serum creatinine and electrolytes; use the lowest NSAID dose for the shortest time.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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