Drug interactions
ibuprofen + lithium
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ lithium levels → toxicity.
Mechanism of action
↓ renal prostaglandins/GFR.
Clinical management
Avoid NSAIDs; use alternatives and monitor levels.
Drug reference
References
Frequently asked questions
Can I take ibuprofen with lithium?
The interaction is rated: Major. ↑ lithium levels → toxicity.
How serious is the interaction between ibuprofen and lithium?
The interaction is rated: Major. Evidence level: High.
How is the interaction between ibuprofen and lithium managed?
Avoid NSAIDs; use alternatives and monitor levels.
Why do ibuprofen and lithium interact?
↓ renal prostaglandins/GFR.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.