Drug interactions
Ibuprofen + Lumacaftor / ivacaftor
Severity: Minor
Ibuprofen and Lumacaftor / ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is an enzyme inducer and may lower exposure to CYP2C9 substrates such as ibuprofen, possibly reducing its analgesic or anti-inflammatory effect. In cystic fibrosis, high-dose ibuprofen is sometimes used, so lower exposure could matter.
What this interaction means in plain words
Ibuprofen and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP2C9 by lumacaftor increases ibuprofen metabolism.
What to do
Monitor clinical response to ibuprofen and adjust the dose as needed. No empirical dose change is generally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Lumacaftor / ivacaftor?
MediHelp rates the interaction as minor. Ibuprofen and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor is an enzyme inducer and may lower exposure to CYP2C9 substrates such as ibuprofen, possibly reducing its analgesic or anti-inflammatory effect. In cystic fibrosis, high-dose ibuprofen is sometimes used, so lower exposure could matter.
How serious is the interaction between Ibuprofen and Lumacaftor / ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to ibuprofen and adjust the dose as needed. No empirical dose change is generally required.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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